The name San Ginesio derives from that of its patron saint, a Christian martyr, whose remains are preserved in the Collegiate Church, the village’s main monument, of Romanesque foundation and with a late Gothic facade. Numerous works of art are preserved inside.

Other notable buildings include the churches of St. Gregory, St. Mary in Vepretis and Sts. Thomas and Barnabas and the “Giacomo Leopardi” Theater, and, finally, four surviving gates of the ancient city walls.

San Ginesio’s museum heritage is collected mainly in the Scipione Gentili Art Gallery.

In the hamlet of San Liberato, included in the Sibillini Mountains National Park, stands the hermitageof San Liberato.

San Ginesio’s signature dish is polentone, made from a local corn variety and served with a mixed meat sauce.

In July and August, the following are held: the International Folklore Festival “The Balcony of the Sibillini” and the historical reenactment “Medievalia,” “Palio of San Ginesio” and “Battle of the Fornarina.”